What is PDRN?

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PDRN (Polydeoxyribonucleotide) is a DNA fragment component extracted from the testes of fish such as salmon. Due to its high similarity to human DNA and excellent biocompatibility, it is widely used in skin repair, regeneration, and aesthetic medical treatments.

What is PDRN?

• PDRN is a polymeric DNA fragment composed of a sequence of deoxyribonucleotides, commonly extracted from the DNA of sperm cells in fish such as salmon and rainbow trout.
• Research indicates that PDRN shares approximately 95–98% similarity with human DNA structure, thereby demonstrating excellent compatibility and safety within skin and tissues.
• Initially, PDRN was applied in medical fields such as aiding the healing of diabetic foot ulcers, chronic wounds, and skin graft wounds. It was later extended to aesthetic injections and skincare ingredients.

How It Works: How Does It Help Skin Repair?

• One of the key mechanisms of PDRN is the activation of adenosine A2A receptors, thereby regulating inflammatory responses, promoting angiogenesis (increasing VEGF expression), and accelerating tissue repair and regeneration.
• It simultaneously provides nucleotides as "repair materials," supporting the so-called DNA "salvage pathway" to help damaged cells repair and divide, thereby accelerating the skin's self-renewal process.
• At the skin level, PDRN promotes collagen synthesis, improves microcirculation, and enhances tissue regeneration, thereby helping to boost skin elasticity, refine texture, and improve overall health.

Types of PDRN Aesthetic Applications

• Injectables: Common treatments include PDRN Skin Booster and Rejuran therapy, which deliver PDRN into the dermis through multi-point injections to target skin texture restoration, acne scar improvement, and fine line reduction.
• Repair Skincare Products: Many serums and masks now incorporate PDRN as a "medical-grade repair ingredient," targeting sensitivity stabilization, redness relief, and accelerated post-procedure recovery.
• Medical Applications: In medical research and certain clinical settings, PDRN is utilized for chronic wounds, transplanted skin flaps, and bone tissue repair, demonstrating its potential in regenerative medicine.

Primary Benefits of PDRN (for Skin)

• Promotes repair and regeneration: Accelerates the repair of the stratum corneum and dermis, helping to improve acne scars, fine lines, and compromised barriers for smoother, more refined skin texture.
• Anti-Inflammatory & Sensitivity Relief: By regulating inflammatory mediators, it helps reduce redness, swelling, and irritation. It is particularly effective for sensitive skin and post-aesthetic procedures.
• Enhance hydration and elasticity: Promotes collagen and matrix production while improving skin hydration levels, resulting in plumper, more resilient, and radiant-looking skin.

How does PDRN differ from treatments like hyaluronic acid?

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In clinical practice, PDRN is often combined with ingredients like hyaluronic acid to achieve both immediate hydration and medium-to-long-term skin restructuring.

Safety, Risks, and Persons for Whom It Is Not Suitable

• Multiple animal and human studies indicate that PDRN exhibits good safety at recommended doses, with low risks of long-term toxicity and systemic side effects.
• When administered via injection, common temporary side effects include: redness, bruising, and mild pain at the injection site, which typically subside within a few days. In extremely rare cases, hypersensitivity or granulation reactions may occur.
• Common contraindications include: individuals under 18 years of age, pregnant or breastfeeding women, those with severe allergies to fish/seafood, autoimmune diseases, poorly controlled diabetes, or infections or open wounds at the injection site. A doctor's evaluation is required to determine suitability.

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